Malvern Panalytical – Zetasizer Core
High-throughput DLS and SLS system for particle sizing, aggregation and colloidal stability analysis. Fast, automated characterization of particle size and aggregation across multiple samples.
Meet the first high-throughput microwell plate reader with built-in Dynamic Light Scattering (DLS), Static Light Scattering (SLS), and Intrinsic Differential Scanning Fluorimetry (DSF).
The Zetasizer Core builds on decades of Malvern Panalytical experience in light scattering and protein characterization. It extends trusted Zetasizer technology into a high-throughput, plate-based workflow designed for biologics discovery, formulation, and development.
Technical Specifications
| Section | Specification | Comment |
| Dynamic Light Scattering (DLS) | ||
| Min volume | 4 uL (1536-well plate) | |
| Min conc, 14 kDa | 0.125 mg/mL | |
| Range, average dH | 0.6 nm – 2000 nm | |
| Min acquisition time | 1 sec | |
| Fitting method | Malvern Panalytical Zetasizer cumulants & multimodal regularization | |
| Advanced acquisition method | Malvern Panalytical Zetasizer Adaptive Correlation | |
| Static Light Scattering (SLS) | ||
| Molar mass range | <1000 Da to 1 MDa | |
| SLS resolution | 5% or 5 kDa, whichever is larger | |
| Sample concentration | 0.05mg/mL – 200mg/mL (protein dependent) | |
| Fluorescence | ||
| Excitation | 280 nm | |
| Detection | 330 & 350 nm | |
| Sample concentration | 0.005mg/mL – 200mg/mL (protein dependent) | |
| Minimum Sample Volumes | ||
| Sample format | 96, 384, 1536 plates | |
| Ultra-low volume (1536) | 4 uL sample | |
| Low volume (384 round) | 10 uL sample | |
| High-quality (384 square) | 40 uL sample | |
| High-volume (96) | 100 uL sample | |
| Instrument Parameters | ||
| Light scattering wavelength | 830 nm | |
| Attenuation range | 1 to 10⁵ | |
| Temperature range | 4 to 95 °C | |
| Max temp ramp | 3 °C/min | |
| Power | 100-240 V AC, 50-60 Hz, Max Power 600 W | |
| Laser Classification | Class 1 | |
| Condensation Control | Purge facility using dry air | |
| Measurement Throughput | ||
| Max samples per minute DSF/SLS | 192 samples per minute | |
| Data | ||
| Thermal stability outputs | Tm, Tonset, Tagg-SLS, Tagg-DLS | |
| Fitting method | Auto-fit with multi-transition support | |
| Applications | ||
| Thermal stability (Tm, Tagg-SLS, Tagg-DLS) | ||
| Long term stability | ||
| Chemical stability (C50) | ||
| Thermal shift assay (EC50) | ||
| Colloidal stability (kD, A2/B22) | ||
| Aggregation state / sizing (diam, PI) – Plus full distribution analysis | ||
| Software & Data Management | ||
| Software | Multi run workbooks | |
| Sample and dispersent databases | ||
| Acquisition-level data review | ||
| 5-clicks software workflow | ||
| Hardware | Barcode reader integration | |
| Plate presence sensor | ||
| Options & Integration | ||
| Robotic handling API* | ||
| OmniTrust (21CFR part 11) compliance package* | ||
| Serviceability | ||
| Modular field replaceable units for minimized downtime | ||
| System self-diagnostic | ||
| HW & SW error and use logging | ||
| Smart Manager (Malvern Panalytical remote support) | ||
| Instrument Dimensions | ||
| Width | 620 mm | |
| Depth | 542 mm | |
| Height | 375 mm | |
| Weight | 29 kg | |
Key Features
- Exceptional data quality at scale: Industry-leading precision for confident, high-throughput decision-making
- Multi-parameter stability insights: Simultaneous measurement of size, colloidal stability, and structural stability
- Advanced thermal control: Precise knowledge of the plate’s thermal profile ensures absolute data reproducibility
- Microwell plate compatibility: Seamless integration with 96-, 384-, and 1536-microwell plates
- Dedicated SLS detector: Transforms B22/second virial coefficient analysis from an expert-only measurement into a routine screening tool
- Impeccable heritage: High-throughput DLS powered by the same trusted algorithms and Adaptive Correlation technology as the market-leading Zetasizer Advance
- Automation ready: Designed for effortless integration into automated robotic workflows, including barcode reader compatibility
- ZS Discover software: Intuitive interface lets users go from sample setup to results in just 5 clicks
Key Industries
- Academia
- Biopharmaceuticals
- Biotechnology
- Pharmaceuticals
Malvern Panalytical was formed by the merger of Malvern Instruments Limited and PANalytical B.V. on 1st January 2017, has headquarters…
